Side effects of antimalarial drugs?
These may be symptoms of a disease.
Quinism.

The Quinism Foundation is a 501(c)(3) nonprofit charitable organization established January 1, 2018 in White River Junction, Vermont
The Quinism Foundation promotes and supports education and research on quinism, the family of medical disorders caused by poisoning by mefloquine, tafenoquine, and related quinoline drugs
Symptoms of neuropsychiatric quinism (also known as chronic quinoline encephalopathy) can mimic those of several psychiatric and neurologic disorders including PTSD and TBI

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Recent press releases

The Quinism Foundation Calls on the CDC to Update its Malaria Prevention Recommendations to Reflect Important FDA Safety Warnings for Tafenoquine and Mefloquine

WHITE RIVER JUNCTION, VT. AUGUST 14, 2018

The Foundation Warns that Psychiatric Symptoms Including Insomnia, Abnormal Dreams, and Nightmares Should be Considered Prodromal to More Serious Adverse Effects

The Quinism Foundation Partners with the National Centre for Trauma to Screen U.K. Veterans for Symptomatic Mefloquine Exposure

WHITE RIVER JUNCTION, VT. JULY 30, 2018

Use of the Two-Question White River Mefloquine Instrument (WRMI-2) Will Permit the National Centre for Trauma to Identify Veterans at Risk of Mefloquine Poisoning

The Quinism Foundation Urges Caution in the Use of Tafenoquine (Krintafel®) for the Prevention of Relapse of P. vivax Malaria

WHITE RIVER JUNCTION, VT. JULY 24, 2018

The Foundation has Shared Its Concerns for the Safety of the Newly-Approved Drug with the Bill & Melinda Gates Foundation and Medicines for Malaria Venture

Executive Director

A message from the Executive Director

Dear Supporter,

The term "quinism" may seem new, but no doubt the symptoms of poisoning by mefloquine (previously marketed as Lariam®), tafenoquine (marketed as Krintafel® and Arakoda™), and related quinoline drugs are all too familiar: Tinnitus. Dizziness. Vertigo. Paresthesias. Visual disturbances. Gastroesophageal and intestinal problems. Nightmares. Insomnia. Sleep apnea. Anxiety. Agoraphobia. Paranoia. Cognitive dysfunction. Depression. Personality change. Suicidal thoughts.

These symptoms are not 'side effects'. They are symptoms of poisoning by a class of drug that is neurotoxic and that injures the brain and brainstem. Poisoning that causes a disease.

This disease has a name. The disease is chronic quinoline encephalopathy — also known as neuropsychiatric quinism.

The Quinism Foundation is a Vermont domestic 501(c)(3) nonprofit charitable organization established to support education and research on chronic quinoline encephalopathy and other medical conditions caused by poisoning, or intoxication, by mefloquine, tafenoquine, and related quinoline drugs.

The foundation has an enormous job ahead. We must prepare healthcare organizations to identify those exposed to quinolines and to screen for symptomatic quinoline exposure. We must educate clinicians to diagnose chronic quinoline encephalopathy and other medical conditions caused by quinoline poisoning. We must train researchers to distinguish the effects of quinism from those of other disorders, including Post-traumatic Stress Disorder (PTSD) and Traumatic Brain Injury (TBI). We must assist government agencies to recognize those suffering disability from quinism. We must identify risk factors for the disease. We must attempt to count all those affected. And, we must support a search for effective treatments.

Please take a moment to sign up for our mailing list. In the coming weeks, you will begin to receive regular updates from the foundation. You will also learn about how to get involved and support the foundation's activities. The foundation is proud to be listed as a registered charity in the PayPal Giving Fund, on Amazon Smile, and in the Facebook donor-advised fund. You can also read more about the foundation’s charitable activities by reviewing our listing on Guidestar.

In the meantime, you can learn more by reading this press release announcing the foundation's incorporation.

On behalf of The Quinism Foundation, I thank you in advance for your support. I am confident that together, we can make a difference in the fight against quinism. I hope that you will join us.

Sincerely,

Remington Nevin, MD, MPH, DrPH
Executive Director, The Quinism Foundation