Side effects of antimalarial drugs? These may be symptoms of a disease.


The Quinism Foundation is a 501(c)(3) nonprofit charitable organization established January 1, 2018 and based in Port Huron, Michigan.

The Quinism Foundation promotes and supports education and research on quinism, the disease caused by poisoning from mefloquine, tafenoquine, chloroquine, and related quinoline drugs.

Symptoms of quinism (also known as chronic quinoline encephalopathy) can mimic those of several psychiatric and neurologic disorders including PTSD and TBI.

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The term “quinism” may seem new, but the symptoms of poisoning from mefloquine (previously marketed as Lariam®), tafenoquine (marketed as Krintafel® and Arakoda®), chloroquine (marketed as Aralen®), and related quinoline drugs are all too familiar: Tinnitus. Dizziness. Vertigo. Paresthesias. Visual disturbances. Gastroesophageal and intestinal problems. Nightmares. Insomnia. Sleep apnea. Anxiety. Agoraphobia. Paranoia. Cognitive dysfunction. Depression. Personality change. Suicidal thoughts.

These symptoms are not “side effects”. They are symptoms of poisoning from a class of drug that is neurotoxic and that injures the brain and brainstem. This poisoning causes a disease, and this disease has a name: Chronic quinoline encephalopathy — also known as quinism.

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